25 Nov 2021
2022 fixtures in full
| RD | DATE | OPPONENT | VENUE | HOME/AWAY | LOCAL TIME |
| 1 | Saturday, Feb 12 (S22) | Toulouse Olympique | Stade Ernest Wallon | Away | 8pm |
| 2 | Saturday, Feb 19 (S22) | Hull KR | John Smiths Stadium | Home | 3pm |
| 3 | Thursday, Feb 24 (S22) | Wigan Warriors | DW Stadium | Away | 8pm |
| 4 | Sunday, Mar 6 (S22) | Salford Red Devils | John Smiths Stadium | Home | 3pm |
| 5 | Saturday, Mar 12 (S22) | Castleford Tigers | John Smiths Stadium | Home | 3pm |
| 6 | Sunday, Mar 20 (S22) | Hull FC | MKM Stadium | Away | 3pm |
| 7 | Friday, Apr 1 (S22) | Catalans Dragons | John Smiths Stadium | Home | 7.45pm |
| 8 | Thursday, Apr 14 (S22) | Leeds Rhinos | Headingley Stadium | Away | 8pm |
| 9 | Monday, Apr 18 (S22) | St Helens | John Smiths Stadium | Home | 3pm |
| 10 | Saturday, Apr 23 (S22) | Warrington Wolves | Halliwell Jones Stadium | Away | 3pm |
| 11 | Thursday, Apr 28 (S22) | Wakefield Trinity | The Mobile Rocket Stadium | Away | 8pm |
| 12 | Friday, May 13 (S22) | Wigan Warriors | John Smiths Stadium | Home | 7.45pm |
| 13 | Friday, May 20 (S22) | Toulouse Olympique | John Smiths Stadium | Home | 7.45pm |
| 14 | Friday, Jun 3 (S22) | Catalans Dragons | Stade Gilbert Brutus | Away | 8.30pm |
| 15 | Friday, Jun 10 (S22) | Leeds Rhinos | John Smiths Stadium | Home | 7.45pm |
| 16 | Sunday, Jun 26 (S22) | Hull KR | Hull College Craven Park | Away | 3pm |
| 17 | Friday, Jul 1 (S22) | Castleford Tigers | The Mend-A-Hose Jungle | Away | 8pm |
| 18 | Sunday, Jul 10 (S22) | Salford Red Devils | St James Park | Home | 1pm |
| 19 | Friday, Jul 15 (S22) | St Helens | Totally Wicked Stadium | Away | 8pm |
| 20 | Friday, Jul 22 (S22) | Catalans Dragons | Stade Gilbert Brutus | Away | 8.30pm |
| 21 | Friday, Jul 29 (S22) | Warrington Wolves | John Smiths Stadium | Home | 7.45pm |
| 22 | Friday, Aug 5 (S22) | Hull FC | John Smiths Stadium | Home | 7.45pm |
| 23 | Sunday, Aug 14 (S22) | Salford Red Devils | AJ Bell Stadium | Away | 3pm |
| 24 | Friday, Aug 19 (S22) | Castleford Tigers | John Smiths Stadium | Home | 7.45pm |
| 25 | Thursday, Aug 25 (S22) | Leeds Rhinos | Headingley Stadium | Away | 8pm |
| 26 | Monday, Aug 29 (S22) | Warrington Wolves | John Smiths Stadium | Home | 3pm |
| 27 | Saturday, Sep 3 (S22) | Wakefield Trinity | John Smiths Stadium | Home | 3pm |
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